James Bartley's Britches

Origin
In 1891, an English ship Star of the East came across a sperm whale, and the efforts to harpoon the creature ultimately ended in one of the boats being upended by the whale's tail, drowning one man whilst prompting the mysterious disappearance of one Mr. James Bartley. The remaining crew began to carve up the whale once it had been killed, and the next morning, upon hauling up the stomach, found an unconscious Mr. Bartley inside, bleached by the gastric juices and stark-raving mad for weeks after, but very much alive. These slacks, in an effort to keep him alive, became an artifact.

Effects
Wearing the pants allows the wearer to be able to breath normally without oxygen, but strips them of their skin pigment and sanity the longer the pants are worn.

This artifact inspired the Disney film "Pinocchio".